Developing better Treatments for Mental Illness
b-neuro™ is a niche service provider of preclinical rodent models of cognition. Our battery of sophisticated cognitive tests and models provides detailed analysis of how a drug candidate can improve cognition across the known domains.
b-neuro provides behavioural testing services with electrophysiology. We analyse how a test agent improves cognitive function by determining its effects on biomarkers of cognitive impairment and the role of gamma oscillations to determine the nature and origin of cognitive processes. Our most recent project is analysis of placental funtion in the mIA model.
b-neuro leverages its experience with the sub-chronic PCP model of cognitive and neurobiological deficits. This model has shown robust impairments across a number of cognitive domains, including working memory, attention, executive function, episodic memory and social behaviour (Neill et al, 2010; 2014; Cadinu et al, 2017). Drug candidates are evaluated for reversal of this deficit across several domains.
b-neuro assesses the effect of agents on cognitive domains affected in schizophrenia, Alzheimer's disease, ADHD and affective disorders.
b-neuro tests compounds at all stages of development: early hits, late leads, preclinical and clinical candidates, and marketed agents.
Why work with b-neuro?
- b-neuro's service is bespoke, reliable, reproducible, and offers well characterised rodent models of cognitive impairment.
- b-neuro's team has over 50 years' experience in animal model development.
- b-neuro's team has a state-of-the-art understanding of ethology, welfare, and validation through negative and positive controls.
- b-neuro's team has a long history and extensive experience in collaborating with partners, including academic teams, small and mid-size biotech, as well as big pharmaceutical companies.
With a specialised array of fully-validated tests, and an integrated approach, b-neuro provides a cost-effective, efficient, cognition testing service with a high standard of quality and accuracy.
In addition to the screening and characterisation of behavioural and biochemical effects of test agents in cognitive models, b-neuro engages in collaborative research with its partners.
b-neuro will apply its know-how and experience to help generate knowledge and answer specific scientific questions of interest to the client.
We operate in an academic environment, and train PhD and MSc students for pharmaceutical companies, NHS and academia.